Sep 10, 15 · We first set up imiquimodinduced dermatitis in mice that closely resembles human psoriasis lesions The development of the lesions is based on the IL23/IL17A axis for phenotypical and histological characteristics Four drugs, 5aminolevulinic acid (ALA), tacrolimus, calcipotriol, and retinoic acid, were used to evaluate percutaneous absorption2 days ago · Furthermore, alantolactone treatment in mice significantly alleviated the severity of skin lesions (erythema, scaling and epidermal thickness, and inflammatory cell infiltration) and decreased the mRNA expression of inflammatory cytokines (eg, TNFα, IL6, IL1β, IL8, IL17A, and IL23) in an IMQinducedlike mouse modelJun 24, 21 · Inhibition with a small molecule inhibitor of the JNK/cJun signaling axis ameliorates skin inflammation in a mouse model of psoriasis, similar to inhibition of IL23 with a blocking antibody, according to Novoszel "Such biologics are highly popular in modern psoriasis therapy, but are expensive," he wrote
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Il-23 psoriasis mouse model
Il-23 psoriasis mouse model-Among these, the interleukin (IL)23/T h 17/IL17 immune pathways play pivotal roles (Lima and Kimball, 10)A recent psoriasis disease modelSpondyloarthritis and psoriasislike disease develop in an IL23dependent fashion in ZAP70mutant SKG mice, which have deficient T cell receptor signaling We characterized curdlan (1,3D βglucan) induced psoriasislike inflammation in SKG mice, investigating the role of IL23, IL22/IL17, regulatory T cells (Tregs) and microbiota
Interleukin 23 And Interleukin 17 Importance In Pathogenesis And Therapy Of Psoriasis
IL23 induced Psoriasis Mouse Model is a convenient, easytouse and affordable mouse model of acute inflammatory response, which is widely used in mechanistic pharmacology of pathology and as a preclinical animal model for drug screening and testing before clinical testing on volunteers psoriatic patientsRecently, a crucial role was proposed for the IL23/IL17 axis in psoriasis We hypothesized that IMQinduced dermatitis in mice can serve as a model for the analysis of pathogenic mechanisms in psoriasislike dermatitis and assessed its IL23/IL17 axis dependencyApplication of IMQ on mouse skin results in the influx of various cells of the immune system, as well as hyperplasia of the epidermis, which is manifested as symptoms that closely resemble human psoriasis in terms of the phenotypic and histological characteristics Moreover, the development of lesions is critically dependent on Il23/IL17
Jun 05, · The KCTie2 mouse is a keratinocytespecific, Tie2overexpressing psoriasis model with cutaneous expression of IL23 and IL17A After treatment with antibodies targeting IL23, IL17A, or IL17RA, the KCTie2 mouse showed a significant improvement in skin inflammation and lengthened occlusive thrombus formation timeInterleukin 17 family (IL17 family) is a family of proinflammatory cystine knot cytokines They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL23Originally, Th17 was identified in 1993 by Rouvier et al who isolated IL17A transcript from a rodent Tcell hybridoma The protein encoded by IL17A is a founding member of IL17 familyNov 21, 17 · When given in an IL23–dependent mouse model for psoriasis, CCL S64C prevented psoriatic inflammation and the upregulation of IL17A and IL22 Our results validate CCR6 as a tractable therapeutic target for psoriasis and demonstrate the value of CCL S64C as a lead compound
Jan 23, 19 · The pathology of psoriasis strongly depends on IL17A Monoclonal antibodies blocking either the cytokine or its receptor are among the most efficient treatments for psoriatic patients Keratinocytes can be activated upon exposure to IL17A and tumor necrosis factorα and secrete secondary cytokines and chemokines in the inflamed skin In psoriasis and its imiquimodinduced mouse modelSeminal studies in experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis, showed that IL23 was responsible for the inflammation observed, notRaychaudhuri et al, 01 ) These were the first mice to hold the promise that an animal model of psoriasis
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Dec 10, 17 · In this review, we discuss recent findings from mouse models, their relevancy to psoriasis and use, including the discovery of new therapies Volume 45 , Issue 3 Special Issue Psoriasis (pages 251–333, e51–e62)Jan 07, 19 · Intradermal injections of IL23 and topical application of Aldara/IMQ induce skin inflammation in mice with features similar to psoriasis—including epidermal hyperplasia and accumulation of inflammatory cells in epidermis and dermis—which is mediated by IL17A, IL22, and other factors implicated in the human diseaseThe IMQinduced psoriasislike inflammation model is based on a single innate antigenic receptor ligand Since it requires no adjuvants, it is considered a clean model from an immunological viewpoint, resem bling most of the features of human psoriatic lesions
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May 19, · All the hallmarks of the human condition are observed in the mouse model (skin involvement, enthesitis and bone changes) directly implicating IL23 in the pathogenesis of PsAPsoriasislike mouse model IL23treated resting macrophages express a distinctive gene expression prolife compared with M1 and M2 macrophages The identification of IL23induced macrophage polarization may help us to understand the contribution of macrophage subpopulation in Th17cytokinesrelated pathogenesisIL23 and ImiquimodInduced Models of Experimental Psoriasis in Mice Genomewide association studies have found that polymorphisms in genes for IL23 and its receptor are important in psoriasis, and blocking IL23 is an effective therapy in the disease
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Interleukin 23 In Psoriasis Integrating New Therapies In The Current Treatment Landscape European Medical Journal
2 days ago · psoriasis model induced by imiquimod (IMQ) is very similar to human psoriasis and has been widely used to induce psoriasis‐like mouse models 24 In this study, our aim was to investigate the therapeutic effects of alantolactone on M5 cytokine‐stimulated keratino‐Jun 25, 13 · We inferred that curcumin was capable of impacting the IL23/IL17A axis by inhibiting IL1β/IL6 and then indirectly downregulating IL17A/IL22 production In conclusion, curcumin can relieve the IMQinduced psoriasislike inflammation in a mouse model, similar to the effects of clobetasolThe IL23/IL17 axis is believed to be particularly important in psoriasis pathogenesis due to its proinflammatory effects IL17 cytokine level is elevated in the imiquimodinduced psoriasis model thus providing a genetically humanized mouse psoriasis model for convenient testing of therapeutics targeting the human IL17A
Stat3 Protein T Helper 17 Cell In Psoriasis By Yousry A Mawla
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Aug 06, · Nakajima K, Kanda T, Takaishi M, et al Distinct role of IL23 and IL17 in the development of psoriasislike lesions in a mouse model J Immunol 11;186(7)Consequently, these models can be used in preclinical studies to investigate the molecular and cellular pathogenesis of psoriasis, as well as in the evaluation of potential therapies This article provides detailed methodologies for creating and evaluating the IL23 and Aldara/IMQinduced mouse models of psoriasisIL23‐Mouse Psoriasis/MAD3 IL23‐Mouse Psoriasis/MAD3 241 240 1196 333 633 333 IL‐23 transcriptomeon Murine Affymetrix Arrays (FDR2) 3500 genes modulated 2346 probes up (1726 unique genes) 2762 probes down (1775 unique genes) About 34% of Psoriasis transcriptomeis in IL23‐Mouse model by these FCH criteria
Il 23 Induces Atopic Dermatitis Like Inflammation Instead Of Psoriasis Like Inflammation In Ccr2 Deficient Mice
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Jun 01, 07 · Spontaneous mouse models A number of spontaneous mouse mutations that give rise to psoriasiform phenotypes have been described ( Sundberg and King, 1996;Apr 04, 17 · IL23induced mouse model of psoriasis The RIGImediated antiviral response leads to activation of the NFjB, which is a major proinflammatory pathway involved in psoriasis (Loo & Gale, 11) Western blot analysis revealed markedly decreased RIGI expression that corresponded to the diminishedCharles River has characterized a clinically relevant psoriasis model in mice through the topical application of 5% imiquimod (IMQ) cream This imiquimodinduced psoriasis models human plaquetype psoriasis in which the IL23/IL17 cytokine axis plays a pivotal role
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Psoriasis is an immunemediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis IL23 is expressed in psoriatic skin, and IL23 injected into the skin of mice produces IL22dependent dermal inflammation and acanthosisJul 01, 18 · In this study, antiIL17C mAb attenuated inflammation in two distinct mouse models of AD and in the IL23–induced psoriasis model It is revealing that although IL23 injection induces psoriasis, the inflammatory gene expression in the skin of treated mice is similar to that described for AD patients ( Ewald et al, 17 )Jul 05, 17 · Besides, when PK2 was over‐expressed in psoriasis‐K14‐VEGF transgenic mouse model, psoriatic lesions were gradually aggravated, as evaluated by increase of redness, swelling, weight, thickness, scaly epidermis, keratinocyte hyper‐proliferation, and increase of IL‐1β, TNFα, IFNγ, IL‐12, IL‐22, IL‐23, IL‐17 in the ear
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Il 23 Induces Atopic Dermatitis Like Inflammation Instead Of Psoriasis Like Inflammation In Ccr2 Deficient Mice
The mannan (Saccharomyces Cerevisiae) induced PsA model (MiP) in mice is a newly developed model in which both skin lesions resembling those seen in Ps as well as the joint inflammation of PsA can be foundDisease is mediated by TNFa produced by macrophages which leads to T cell activation and IL17A production The increased level of IL17A recruit neutrophils to joint andIn mouse studies, IL22 has been directly linked as a key downstream mediator of IL23–induced psoriasislike inflammation in skin That is, IL23 injected into mouse ears caused psoriasislike disease that was dependent upon Th17 cell infiltration into the skin and IL22 production by the Th17 cells 33••Mar 16, 21 · Based on genetically engineered mouse models (GEMMs) and human psoriasis biopsies, this study suggests that cJun in Dendritic Cells (DC) contributes to psoriasis by controlling CCL2 and IL23 production, and further identifies the JNK/cJun axis as a
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Feb , 18 · In this study, antiIL17C mAb attenuated inflammation in two distinct mouse models of AD and in the IL23–induced psoriasis model It is revealing that although IL23 injection induces psoriasis, the inflammatory gene expression in the skinApr 01, 18 · Introduction Psoriasis is a chronic immunemediated inflammatory skin disorder (Schön and Boehncke, 05)Many cytokines and immune cells have been identified that promote the disease initiation and propagation (Schön and Boehncke, 05);Apr 28, 21 · Topical application of SHR in Vaseline exhibited excellent efficacy in the imiquimodinduced and IL23induced psoriasislike skin inflammation mouse models and correlated with the reduction of Th17 pathway cytokines, IL6, TNFα and IL17A
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Hypothesis of cytokine hierarchy for psoriasis development IL23 in mice (19, 35) The current study also demonstrates a role based on our mouse model IL23 is upstream of the "cytokine flow" that for IL23 in psoriasis via comparable efficacy of Abs to IL12/ contributes to psoriatic changeJun 22, 21 · They used a mouse model to study the effect of diet on psoriasis and psoriatic arthritis They injected mice with Interleukin23 (IL23) minicircle DNA to induce a response mimicking psoriasisIL23Induced Psoriasis Model Representative data figures for mouse IL23induced psoriasis Species available Mouse IL23 Psoriasis, Rat IL23 Psoriasis Recent research in psoriasis has been focused on the IL23/Th17 pathway IL23 stimulates and promotes differentiation of Th17 cells IL23 is a heterodimeric cytokine with two subunits
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Figure 3 From Andrographolide Alleviates Imiquimod Induced Psoriasis In Mice Via Inducing Autophagic Proteolysis Of Myd Semantic Scholar
The IL23 induced psoriasis model involves the injection of IL23 into the ear of C57Bl/6 and is dependent on IL22 for the development of dermal inflammation and acanthosis IL22 induces keratinocyte proliferation and epidermal hyperplasia contributing to epidermis thickeningSep 23, 17 · In this review, we discuss recent findings from mouse models, their relevancy to psoriasis and use, including the discovery of new therapies Key words immune system, keratinocytes, mouse model, psoriasis, signal transducer and activator of transcription 3 INTRODUCTION Psoriasis is one of the most common inflammatory disordersThe imiquimodinduced model of psoriasis is a simple model that has been used with increasing frequency to better understand the inflammatory process leading to psoriasis, as well as a highthroughput screening of potential therapeutic agents
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Sep 28, 10 · Two other cytokines, IL12 and IL23, have a key role in psoriasis and therapies to target these interleukins are in clinical trials 66,67,68 Interestingly, transgenic mice that
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